Tel: +44 (0)20 7691 0984 | contact@transpharmation.co.uk
 

Molecular Biomarkers

Transpharmation’s translational molecular biomarker platform facilitates the diagnosis and classification of CNS disorders, stratifying patients into homogeneous, clinically distinct subpopulations and helping to predict treatment response to specific drugs.
 

Our platform provides services which can stand-alone or can be coupled with all our preclinical and experimental medicine models to facilitate decision making in drug discovery projects. Furthermore, a partnership with a CNS focused biobank provides access to tissue, fluids and full clinical histories of patients from a range of neurological and psychiatric disorders.

Cutting-edge high-performance infrared (Odyssey® CLx Imaging System) and electrochemiluminescence (MESO® QuickPlex SQ 120) technologies facilitate detection of proteins in the brain, spinal cord, cerebrospinal fluid (CSF), plasma and blood cells; and the detection of cytokines, Total-TAU / Phospho-Tau and alpha-synuclein in tissue and fluids.

All our protocols can be customised to detect your proteins of interest.

Examples of the models we offer:

  • Infrared detection of molecular biomarkers
    • Synaptic Remodelling: Spinophilin, Synaptophysin, PSD-95, Parvalbumin, NCAM/PSA-NCAM
    • Cytoskeletal / Microtubular Proteins : a-tubulin Post-Translational modifications, Tubulin Isotypes (a and b), Phospho-MAP2/MAP2, Phospho-TAU/TAU, STOP (MAP6), +TIPs (e.g.:CLIP170)
    • Neurotrophic Factors: BDNF, NGF, VGF, NT-3, NT-4,Trk receptors
    • Protein Kinases: GSK3b, PKA, PKC
    • mTOR Signalling : Phospho-mTOR/mTOR, Phospho-p70S6K/p70S6K,Phospho-4E-BP1/4E-BP1
  • Multiplexed detection of cytokines – IFNγ, IL-1β, IL-4, IL-5, IL-6, KC/GRO, IL-10, IL-13, TNF-α

pain1This list is not exhaustive, we are always developing new areas of discovery within our preclinical field of expertise. If there is something particular that is not listed here please do contact us.

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