Acute and chronic inflammatory pain models have been used routinely by the pharmaceutical industry to provide information that helps to guide strategic decision-making around the mechanism of action and efficacy of molecules targeting inflammatory pain as well as providing robust pharmacodynamic end-points.
Examples of the models we offer include:
- CFA / carrageenan / capsaicin / formalin induced local inflammatory pain
- MIA / CFA osteoarthritis joint pain
- Acute mechanistic pain models (e.g. NGF)
- Ultraviolet light (UV) burn
- LPS-induced inflammation (cytokine and chemokine release)
Examples of end points:
- Weight-bearing (mechanical hypersensitivity)
- Hargeaves (thermal hyperalgesia)
- Von Frey hairs (tactile allodynia)
- Randall Selitto (tactile hyperalgesia)
- Plethysmometer (paw volume)
- Hot/cold plate (allodynia)
- LABORAS automated complex behavioural assessment (e.g. locomotor activity)
- EEG/sleep
- Inflammatory cytokine analysis (e.g. synovial fluid markers)
- PK sampling
This list is not exhaustive, we are always developing new areas of discovery within our preclinical field of expertise. If there is something particular that is not listed here please do contact us.
