Sleep Model Research
Transpharmation has a world-class reuputation in the field of Sleep / EEG research contributing valuable data to the field. Our expertise in this field stems from years of experience and research conducted by our management team whilst at GSK, on the central arousal effect of the hypothalamic neuropeptide orexin-A, research which proved pivotal in guiding the discovery and development of novel orexin receptor antagonists which is applicable for a range of sleep disorders. At Transpharmation, we benchmark compounds against clinically relevant standards such as zolpidem and modafinil to evaluate CNS stimulant or sedative/hypnotic properties on sleep/wake cycles in rodents; supporting our clients in the development of novel molecules for a range of therapeutic indications, including sleep disorders.
You can rely on us to be flexible and reliable to provide proven data in a timely fashion. Animal welfare is vital to our studies and we genuinely care about any animals involved in our projects.
Examples of sleep models we offer include:
- Sleep/wake profiling, including Wistar Kyoto rats
- Quantitative EEG
- Mismatch negativity
Examples of project end points include:
- REM, non-REM, latency to sleep onset, paradoxical sleep quantification etc.
- Power spectral band analysis – delta, theta, gamma, beta, alpha frequencies
- PK analysis
Tell us about your Sleep Model requirements
This list of sleep model services is not exhaustive, we are always developing new areas of discovery within our preclinical field of expertise. If there is something particular that is not outlined here please contact us to discuss.
