Gastrointestinal (GI) Disorders

Transpharmation currently offers a number of assays of in vivo intestinal motility in the rat but also, critically from a translational perspective, human tissue.

Working with our collaborator and clinical network, we can offer human gastrointestinal tract tissue (e.g. stomach and colon) from ‘normal’ patients and those with various bowel disorders (e.g. IBS).

Gastric emptying

  • Rat in vivo: emptying of semi-solid, nutrient based meal
  • Human in vitro: changes in cholinergic activity benchmarked vs. clinical standards

Defecation

  • Rodent in vivo: defecation ± stimuli to introduce diarrhoea/constipation
  • Rodent in vivo: bead expulsion test

Intestinal motility and secretion

  • Human in vitro: changes in neuromuscular activity benchmarked vs. clinical standards
  • Human in vitro: peristaltic reflex
  • Human in vitro: change in short-circuit current in colon mucosa

Supported by immunohistochemistry

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Preclinical
Pain
Inflammatory Pain
Neuropathic pain
Cognitive Disorders
Gastrointestinal Disorders
Sleep Disorders
Epilepsy
Depression & Anxiety
PK/PD studies
Schizophrenia
Molecular Biomarkers