Gastrointestinal (GI) Disorders
Transpharmation currently offers a number of assays of in vivo intestinal motility in the rat but also, critically from a translational perspective, human tissue.
Working with our collaborator and clinical network, we can offer human gastrointestinal tract tissue (e.g. stomach and colon) from ‘normal’ patients and those with various bowel disorders (e.g. IBS).
- Rat in vivo: emptying of semi-solid, nutrient based meal
- Human in vitro: changes in cholinergic activity benchmarked vs. clinical standards
- Rodent in vivo: defecation ± stimuli to introduce diarrhoea/constipation
- Rodent in vivo: bead expulsion test
Intestinal motility and secretion
- Human in vitro: changes in neuromuscular activity benchmarked vs. clinical standards
- Human in vitro: peristaltic reflex
- Human in vitro: change in short-circuit current in colon mucosa
Supported by immunohistochemistry
|Contact us to request a full dataset on our preclinical and human tissue GI capabilities.|